TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Benign Tumors Total 383/402(95.3%) 312/401(77.8%) Mean(sd) 95.3%(3.0) 77.8%(4.1) Range 45/50 - 49/50 36/50 - 41/50 Males 49/50 45/50 45/49 48/51 49/50 48/50 49/50 50/52 Females 37/50 36/50 37/50 41/50 41/50 39/50 41/50 40/51 --------------------------------------------------------------------------- Malignant Tumors Total 175/402(43.5%) 145/401(36.2%) Mean(sd) 43.6%(7.7) 36.2%(8.4) Range 16/51 - 28/50 10/50 - 24/50 Males 23/50 24/50 17/49 16/51 23/50 28/50 22/50 22/52 Females 18/50 24/50 10/50 15/50 21/50 19/50 20/50 18/51 --------------------------------------------------------------------------- Malignant and Benign Total 386/402(96%) 357/401(89%) Tumors Mean(sd) 96.0%(3.2) 89.0%(4.2) Range 45/50 - 50/50 41/50 - 48/50 Males 49/50 45/50 46/49 48/51 49/50 48/50 50/50 51/52 Females 44/50 44/50 41/50 46/50 44/50 46/50 48/50 44/51 --------------------------------------------------------------------------- Hemangioma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/402(0.2%) 1/401(0.2%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma or Total 1/402(0.2%) 1/401(0.2%) Hemangioma Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 2/402(0.5%) 2/401(0.5%) Mean(sd) 0.5%(1.4) 0.5%(0.9) Range 0/50 - 2/50 0/50 - 1/50 Males 2/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 108/402(26.9%) 93/401(23.2%) Monocytic, Mononuclear, Mean(sd) 26.9%(8.8) 23.2%(7.0) or Undifferentiated Range 8/49 - 22/50 6/50 - 17/50 Males 15/50 10/50 8/49 10/51 13/50 22/50 16/50 14/52 Females 10/50 14/50 6/50 10/50 14/50 17/50 13/50 9/51 --------------------------------------------------------------------------- Malignant Lymphoma: Total 0/402(0%) 0/401(0%) Histiocytic, Mean(sd) 0.0%(0.0) 0.0%(0.0) Lymphocytic, Mixed, NOS, Range 0/50 - 0/50 0/50 - 0/50 or Undifferentiated Cell Type Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mesothelioma: Benign Total 4/402(1%) 0/401(0%) Mean(sd) 1.0%(2.8) 0.0%(0.0) Range 0/50 - 4/50 0/50 - 0/50 Males 0/50 4/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 12/402(3%) 1/401(0.2%) Malignant, NOS Mean(sd) 3.0%(2.8) 0.3%(0.7) Range 0/51 - 4/50 0/50 - 1/50 Males 1/50 4/50 1/49 0/51 1/50 0/50 3/50 2/52 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 7/402(1.7%) 0/401(0%) Mean(sd) 1.7%(2.2) 0.0%(0.0) Range 0/50 - 3/50 0/50 - 0/50 Males 1/50 0/50 0/49 0/51 1/50 0/50 3/50 2/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 2/402(0.5%) 1/401(0.2%) Mean(sd) 0.5%(0.9) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 1/50 1/50 0/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 2/402(0.5%) 1/401(0.2%) Mean(sd) 0.5%(0.9) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 1/50 1/50 0/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/401(0%) 4/400(1%) Mean(sd) 0.0%(0.0) 1.0%(1.1) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 1/50 1/50 1/50 0/50 1/49 0/51 --------------------------------------------------------------------------- Carcinoma Total 1/401(0.2%) 0/400(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/51 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Ganglioneuroma Total 0/401(0%) 1/400(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/49 0/51 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 94/401(23.4%) 18/400(4.5%) Mean(sd) 23.5%(7.0) 4.5%(3.4) Range 7/50 - 17/50 0/50 - 5/49 Males 7/50 13/50 9/49 17/50 15/50 14/50 10/50 9/52 Females 2/50 0/50 3/50 1/50 1/50 4/50 5/49 2/51 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 2/401(0.5%) 1/400(0.3%) Mean(sd) 0.5%(0.9) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/50 1/50 0/50 1/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/49 0/51 --------------------------------------------------------------------------- Pheochromocytoma Total 8/401(2%) 3/400(0.8%) Malignant Mean(sd) 2.0%(1.9) 0.8%(1.5) Range 0/49 - 3/50 0/50 - 2/49 Males 1/50 1/50 0/49 1/50 0/50 3/50 1/50 1/52 Females 0/50 0/50 0/50 1/50 0/50 0/50 2/49 0/51 --------------------------------------------------------------------------- Pheochromocytoma: Total 101/401(25.2%) 22/400(5.5%) Benign, Complex, Mean(sd) 25.2%(7.8) 5.5%(4.3) Malignant, NOS Range 8/50 - 18/50 0/50 - 7/49 Males 8/50 14/50 9/49 18/50 16/50 16/50 11/50 9/52 Females 3/50 0/50 3/50 2/50 1/50 4/50 7/49 2/51 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibrosarcoma Total 0/397(0%) 0/399(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/48 0/47 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Chondroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Chondrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Chondrosarcoma or Total 0/402(0%) 0/401(0%) Chondroma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Chordoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 1/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 1/402(0.2%) 1/401(0.2%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 0/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/402(0.2%) 1/401(0.2%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 0/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Astrocytoma Benign Total 1/397(0.3%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Astrocytoma Malignant Total 3/397(0.8%) 1/401(0.2%) Mean(sd) 0.8%(1.0) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/50 0/47 0/48 1/50 1/50 1/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Glioma Malignant Total 0/397(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Glioma NOS Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/397(0%) 0/401(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/397(0%) 0/401(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Meningioma Benign Total 1/397(0.3%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/48 0/50 - 0/50 Males 0/50 0/50 0/47 1/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Meningioma Malignant Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Meningioma: Benign, Total 1/397(0.3%) 0/401(0%) Malignant, NOS Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/48 0/50 - 0/50 Males 0/50 0/50 0/47 1/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/397(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Oligodendroglioma Total 0/397(0%) 0/401(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/397(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Oligodendroglioma, Total 4/397(1%) 4/401(1%) Glioma, or Astrocytoma Mean(sd) 1.0%(1.1) 1.0%(1.5) Range 0/50 - 1/50 0/50 - 2/51 Males 0/50 1/50 0/47 0/48 1/50 1/50 1/50 0/52 Females 1/50 1/50 0/50 0/50 0/50 0/50 0/50 2/51 --------------------------------------------------------------------------- Sarcoma Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/397(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/47 0/48 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 26/390(6.7%) 29/383(7.6%) Mean(sd) 6.7%(5.8) 7.6%(4.8) Range 0/50 - 8/47 0/48 - 8/49 Males 0/50 6/49 2/45 8/47 1/50 2/48 5/49 2/52 Females 4/49 8/49 0/48 3/47 2/50 3/46 5/46 4/48 --------------------------------------------------------------------------- Carcinoma Total 11/390(2.8%) 8/383(2.1%) Mean(sd) 2.8%(2.7) 2.1%(3.6) Range 0/48 - 3/47 0/49 - 5/49 Males 3/50 2/49 1/45 3/47 2/50 0/48 0/49 0/52 Females 0/49 5/49 0/48 2/47 1/50 0/46 0/46 0/48 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 37/390(9.5%) 37/383(9.7%) Mean(sd) 9.6%(6.9) 9.6%(7.6) Range 2/52 - 11/47 0/48 - 13/49 Males 3/50 8/49 3/45 11/47 3/50 2/48 5/49 2/52 Females 4/49 13/49 0/48 5/47 3/50 3/46 5/46 4/48 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/390(0%) 0/383(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/49 0/45 0/47 0/50 0/48 0/49 0/52 Females 0/49 0/49 0/48 0/47 0/50 0/46 0/46 0/48 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/390(0%) 0/383(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/49 0/45 0/47 0/50 0/48 0/49 0/52 Females 0/49 0/49 0/48 0/47 0/50 0/46 0/46 0/48 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma NOS Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Melanoma NOS Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibroma Total 0/401(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/401(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/401(0%) 3/401(0.7%) Mean(sd) 0.0%(0.0) 0.8%(2.1) Range 0/50 - 0/50 0/50 - 3/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 3/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma NOS Total 0/401(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Hemangiosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 28/397(7.1%) 9/400(2.3%) Mean(sd) 7.0%(5.8) 2.3%(1.7) Range 0/50 - 9/50 0/50 - 2/50 Males 0/50 0/49 4/47 4/49 2/50 4/50 9/50 5/52 Females 0/50 0/50 1/49 2/50 1/50 2/50 2/50 1/51 --------------------------------------------------------------------------- Carcinoma Total 7/397(1.8%) 2/400(0.5%) Mean(sd) 1.8%(2.3) 0.5%(0.9) Range 0/47 - 3/50 0/50 - 1/50 Males 3/50 2/49 0/47 0/49 1/50 0/50 1/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 1/50 1/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 35/397(8.8%) 11/400(2.8%) Mean(sd) 8.8%(4.9) 2.7%(2.1) Range 2/49 - 10/50 0/50 - 3/50 Males 3/50 2/49 4/47 4/49 3/50 4/50 10/50 5/52 Females 0/50 0/50 1/49 2/50 1/50 2/50 3/50 2/51 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Papilloma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 3/400(0.8%) 1/400(0.3%) Mean(sd) 0.7%(1.0) 0.3%(0.7) Range 0/49 - 1/50 0/50 - 1/50 Males 0/49 1/50 1/49 0/50 0/50 0/50 0/50 1/52 Females 0/50 0/50 0/49 1/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 2/400(0.5%) 0/400(0%) Mean(sd) 0.5%(1.4) 0.0%(0.0) Range 0/49 - 2/50 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 2/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/400(1.3%) 1/400(0.3%) Mean(sd) 1.2%(1.5) 0.3%(0.7) Range 0/49 - 2/50 0/50 - 1/50 Males 0/49 1/50 1/49 0/50 0/50 2/50 0/50 1/52 Females 0/50 0/50 0/49 1/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Lipoma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Nephroblastoma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/400(0%) 1/400(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Stromal Nephroma Total 0/400(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Cholangiocarcinoma Total 0/400(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Cholangioma Total 1/400(0.3%) 0/401(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/50 1/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/400(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 12/400(3%) 1/401(0.2%) Mean(sd) 3.0%(3.0) 0.3%(0.7) Range 0/50 - 4/50 0/50 - 1/50 Males 2/50 0/50 0/49 0/49 2/50 4/50 1/50 3/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 4/400(1%) 0/401(0%) Mean(sd) 1.0%(1.8) 0.0%(0.0) Range 0/50 - 2/49 0/50 - 0/50 Males 0/50 0/50 2/49 0/49 0/50 0/50 0/50 2/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hepatocellular Total 4/400(1%) 0/401(0%) Carcinoma or Mean(sd) 1.0%(1.8) 0.0%(0.0) Hepatoblastoma Range 0/50 - 2/49 0/50 - 0/50 Males 0/50 0/50 2/49 0/49 0/50 0/50 0/50 2/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hepatocellular Total 16/400(4%) 1/401(0.2%) Carcinoma or Mean(sd) 4.0%(3.5) 0.3%(0.7) Hepatocellular Adenoma Range 0/50 - 5/52 0/50 - 1/50 Males 2/50 0/50 2/49 0/49 2/50 4/50 1/50 5/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hepatocellular Total 16/400(4%) 1/401(0.2%) Carcinoma, Mean(sd) 4.0%(3.5) 0.3%(0.7) Hepatocellular Adenoma, Range 0/50 - 5/52 0/50 - 1/50 or Hepatoblastoma Males 2/50 0/50 2/49 0/49 2/50 4/50 1/50 5/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Alveolar/Bronchiolar Total 11/401(2.7%) 4/401(1%) Adenoma Mean(sd) 2.7%(1.5) 1.0%(1.5) Range 0/50 - 2/50 0/50 - 2/50 Males 2/50 0/50 1/49 2/50 2/50 1/50 2/50 1/52 Females 0/50 0/50 0/50 1/50 0/50 1/50 2/50 0/51 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 3/401(0.7%) 0/401(0%) Carcinoma Mean(sd) 0.8%(1.5) 0.0%(0.0) Range 0/49 - 2/50 0/50 - 0/50 Males 1/50 2/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 14/401(3.5%) 4/401(1%) Carcinoma or Mean(sd) 3.5%(1.4) 1.0%(1.5) Alveolar/Bronchiolar Range 1/52 - 3/50 0/50 - 2/50 Adenoma Males 3/50 2/50 1/49 2/50 2/50 1/50 2/50 1/52 Females 0/50 0/50 0/50 1/50 0/50 1/50 2/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 1/401(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 1/401(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 1/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/401(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/401(0.2%) 0/401(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 1/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Plasma Cell Tumor Total 0/402(0%) 0/401(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Hemangiosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Plasma Cell Tumor Total 0/402(0%) 0/401(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Hemangiosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoacanthoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Adenoma Total 2/402(0.5%) 5/401(1.2%) Mean(sd) 0.5%(0.9) 1.3%(2.1) Range 0/50 - 1/51 0/50 - 3/50 Males 0/50 0/50 0/49 1/51 0/50 1/50 0/50 0/52 Females 0/50 0/50 1/50 0/50 0/50 3/50 1/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 2/402(0.5%) 8/401(2%) Mean(sd) 0.5%(0.9) 2.0%(1.5) Range 0/50 - 1/50 0/50 - 2/50 Males 1/50 0/50 0/49 0/51 0/50 0/50 0/50 1/52 Females 1/50 2/50 1/50 0/50 2/50 0/50 1/50 1/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/402(1%) 13/401(3.2%) Mean(sd) 1.0%(1.1) 3.3%(1.8) Range 0/50 - 1/50 0/50 - 3/50 Males 1/50 0/50 0/49 1/51 0/50 1/50 0/50 1/52 Females 1/50 2/50 2/50 0/50 2/50 3/50 2/50 1/51 --------------------------------------------------------------------------- Fibroadenoma Total 23/402(5.7%) 132/401(32.9%) Mean(sd) 5.7%(1.3) 32.9%(7.2) Range 2/50 - 4/50 13/50 - 22/50 Males 3/50 2/50 3/49 3/51 3/50 4/50 2/50 3/52 Females 22/50 13/50 17/50 14/50 22/50 14/50 15/50 15/51 --------------------------------------------------------------------------- Fibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 25/402(6.2%) 135/401(33.7%) or Adenoma Mean(sd) 6.2%(2.0) 33.7%(7.0) Range 2/50 - 5/50 13/50 - 22/50 Males 3/50 2/50 3/49 4/51 3/50 5/50 2/50 3/52 Females 22/50 13/50 18/50 14/50 22/50 15/50 16/50 15/51 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 26/402(6.5%) 142/401(35.4%) Carcinoma, or Adenoma Mean(sd) 6.5%(2.0) 35.4%(7.9) Range 2/50 - 5/50 14/50 - 24/50 Males 3/50 2/50 3/49 4/51 3/50 5/50 2/50 4/52 Females 23/50 14/50 19/50 14/50 24/50 15/50 17/50 16/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Lipoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Lipoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/401(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/401(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Chondroma Total 0/401(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Chondrosarcoma Total 0/401(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 1/401(0.2%) 0/400(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 1/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Osteoma Total 0/401(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/401(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 2/401(0.5%) 0/400(0%) Mean(sd) 0.5%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 1/50 0/50 0/50 1/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/401(0.2%) 0/400(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/50 0/50 1/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Papilloma Squamous or Total 3/402(0.7%) 2/401(0.5%) Papilloma Mean(sd) 0.8%(1.5) 0.5%(0.9) Range 0/50 - 2/50 0/50 - 1/50 Males 2/50 0/50 1/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 1/50 0/50 1/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/402(0.2%) 2/401(0.5%) Mean(sd) 0.3%(0.7) 0.5%(0.9) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Squamous Cell Total 4/402(1%) 4/401(1%) Carcinoma, Papilloma Mean(sd) 1.0%(1.5) 1.0%(1.1) Squamous, or Papilloma Range 0/50 - 2/50 0/50 - 1/50 Males 2/50 0/50 1/49 0/51 0/50 0/50 1/50 0/52 Females 1/50 0/50 0/50 0/50 1/50 0/50 1/50 1/51 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 2/401(0.5%) Mean(sd) 0.5%(0.9) Range 0/50 - 1/50 Females 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/401(0.2%) Benign Mean(sd) 0.3%(0.7) Range 0/50 - 1/51 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/401(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 1/401(0.2%) Benign, Malignant, NOS Mean(sd) 0.3%(0.7) Range 0/50 - 1/51 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/401(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/401(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Luteoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/401(0%) Tumor, Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 41/397(10.3%) 1/398(0.3%) Mean(sd) 10.2%(8.6) 0.3%(0.7) Range 1/49 - 12/50 0/50 - 1/50 Males 10/50 1/49 1/47 2/49 12/50 2/50 5/50 8/52 Females 1/50 0/50 0/49 0/48 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 1/397(0.3%) 0/398(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/49 0/47 0/49 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 42/397(10.6%) 1/398(0.3%) Mean(sd) 10.5%(9.1) 0.3%(0.7) Range 1/49 - 13/50 0/50 - 1/50 Males 10/50 1/49 1/47 2/49 13/50 2/50 5/50 8/52 Females 1/50 0/50 0/49 0/48 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/397(0.3%) 0/398(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/49 0/47 0/49 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Mixed Tumor Benign Total 2/397(0.5%) 0/398(0%) Mean(sd) 0.5%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/49 0/47 0/49 0/50 0/50 1/50 1/52 Females 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 1/374(0.3%) 0/374(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/49 - 1/41 0/49 - 0/49 Males 0/49 0/47 1/41 0/47 0/46 0/48 0/47 0/49 Females 0/49 0/46 0/46 0/42 0/48 0/48 0/47 0/48 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Paraganglioma Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/402(0%) 0/401(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Squamous Cell Carcinoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/402(0.2%) 2/401(0.5%) Mean(sd) 0.3%(0.7) 0.5%(0.9) Range 0/50 - 1/49 0/50 - 1/50 Males 0/50 0/50 1/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 1/50 0/50 1/50 0/51 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 138/395(34.9%) 205/395(51.9%) Mean(sd) 34.9%(9.1) 51.9%(8.5) Range 9/48 - 24/49 19/50 - 31/49 Males 19/50 16/48 19/48 24/49 14/50 16/50 9/48 21/52 Females 22/47 19/50 30/49 31/49 26/50 26/49 28/50 23/51 --------------------------------------------------------------------------- Carcinoma Total 2/395(0.5%) 3/395(0.8%) Mean(sd) 0.5%(1.5) 0.8%(1.5) Range 0/50 - 2/48 0/47 - 2/50 Males 0/50 2/48 0/48 0/49 0/50 0/50 0/48 0/52 Females 0/47 2/50 1/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 140/395(35.4%) 208/395(52.7%) Mean(sd) 35.4%(9.1) 52.7%(8.0) Range 9/48 - 24/49 21/50 - 31/49 Males 19/50 18/48 19/48 24/49 14/50 16/50 9/48 21/52 Females 22/47 21/50 31/49 31/49 26/50 26/49 28/50 23/51 --------------------------------------------------------------------------- Craniopharyngioma Total 0/395(0%) 1/395(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/47 - 1/50 Males 0/50 0/48 0/48 0/49 0/50 0/50 0/48 0/52 Females 0/47 1/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Ganglioneuroma Total 1/395(0.3%) 0/395(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/47 - 0/47 Males 0/50 0/48 0/48 0/49 1/50 0/50 0/48 0/52 Females 0/47 0/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/395(0%) 0/395(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/47 - 0/47 Males 0/50 0/48 0/48 0/49 0/50 0/50 0/48 0/52 Females 0/47 0/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/395(0%) 0/395(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/47 - 0/47 Males 0/50 0/48 0/48 0/49 0/50 0/50 0/48 0/52 Females 0/47 0/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/395(0%) 0/395(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/47 - 0/47 Males 0/50 0/48 0/48 0/49 0/50 0/50 0/48 0/52 Females 0/47 0/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/395(0%) 0/395(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/47 - 0/47 Males 0/50 0/48 0/48 0/49 0/50 0/50 0/48 0/52 Females 0/47 0/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/388(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/45 0/45 0/50 0/48 0/48 0/52 --------------------------------------------------------------------------- Carcinoma Total 0/388(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/45 0/45 0/50 0/48 0/48 0/52 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/388(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/45 0/45 0/50 0/48 0/48 0/52 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.2%(0.7) 0.0%(0.0) Range 0/50 - 1/52 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 1/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/402(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibrosarcoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Lipoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/402(0%) 0/401(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Basal Cell Adenoma Total 3/402(0.7%) 1/401(0.2%) Mean(sd) 0.8%(1.5) 0.3%(0.7) Range 0/50 - 2/50 0/50 - 1/51 Males 0/50 0/50 1/49 0/51 2/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 4/402(1%) 1/401(0.2%) Basosquamous Tumor Mean(sd) 1.0%(1.5) 0.3%(0.7) Benign Range 0/50 - 2/50 0/50 - 1/51 Males 0/50 0/50 1/49 1/51 2/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 5/402(1.2%) 1/401(0.2%) Basosquamous Tumor Mean(sd) 1.3%(1.5) 0.3%(0.7) Benign, or Range 0/50 - 2/50 0/50 - 1/51 Trichoepithelioma Males 0/50 0/50 1/49 1/51 2/50 0/50 1/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 1/402(0.2%) 0/401(0%) or Basosquamous Tumor Mean(sd) 0.3%(0.7) 0.0%(0.0) (malignant or NOS) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 6/402(1.5%) 1/401(0.2%) Basal Cell Adenoma, Mean(sd) 1.5%(1.4) 0.3%(0.7) Basosquamous Tumor Range 0/50 - 2/50 0/50 - 1/51 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 1/50 1/49 1/51 2/50 0/50 1/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Basal or Sq. Cell Total 32/402(8%) 7/401(1.7%) Carcinoma, Carcinoma, Mean(sd) 8.0%(3.7) 1.8%(2.0) Basosq. Tumor (M or B), Range 2/50 - 7/50 0/50 - 3/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 2/50 7/50 2/49 5/51 6/50 3/50 3/50 4/52 Females 0/50 1/50 1/50 0/50 3/50 0/50 1/50 1/51 --------------------------------------------------------------------------- Basosquamous Tumor Total 1/402(0.2%) 0/401(0%) Benign Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 0/50 0/49 1/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Basosquamous Tumor Total 1/402(0.2%) 0/401(0%) Malignant Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/402(0.2%) 1/401(0.2%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 --------------------------------------------------------------------------- Keratoacanthoma Total 18/402(4.5%) 1/401(0.2%) Mean(sd) 4.5%(3.8) 0.3%(0.7) Range 0/49 - 6/50 0/50 - 1/50 Males 2/50 6/50 0/49 2/51 3/50 0/50 2/50 3/52 Females 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Lipoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Liposarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Melanoma Benign Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Melanoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 1/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 2/402(0.5%) 3/401(0.7%) Mean(sd) 0.5%(0.9) 0.8%(1.0) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 1/50 0/50 1/52 Females 0/50 1/50 1/50 0/50 0/50 0/50 1/50 0/51 --------------------------------------------------------------------------- Squamous Cell Total 3/402(0.7%) 3/401(0.7%) Carcinoma, Basal Cell Mean(sd) 0.7%(1.0) 0.8%(1.0) Carcinoma, Basosquamous Range 0/50 - 1/50 0/50 - 1/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 1/50 0/49 0/51 0/50 1/50 0/50 1/52 Females 0/50 1/50 1/50 0/50 0/50 0/50 1/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 6/402(1.5%) 3/401(0.7%) Mean(sd) 1.5%(1.8) 0.8%(2.1) Range 0/50 - 2/50 0/50 - 3/50 Males 0/50 0/50 1/49 2/51 1/50 2/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 3/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Total 6/402(1.5%) 3/401(0.7%) Papilloma or Papilloma Mean(sd) 1.5%(1.8) 0.8%(2.1) Range 0/50 - 2/50 0/50 - 3/50 Males 0/50 0/50 1/49 2/51 1/50 2/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 3/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Total 26/402(6.5%) 6/401(1.5%) Papilloma, Papilloma, Mean(sd) 6.4%(3.1) 1.5%(2.1) Squamous Cell Carcinoma Range 1/49 - 6/50 0/50 - 3/50 or Keratoacanthoma Males 2/50 6/50 1/49 4/51 4/50 3/50 2/50 4/52 Females 0/50 1/50 1/50 0/50 3/50 0/50 1/50 0/51 --------------------------------------------------------------------------- Squamous Cell Total 24/402(6%) 3/401(0.7%) Papilloma, Papilloma, or Mean(sd) 6.0%(3.2) 0.8%(2.1) Keratoacanthoma Range 1/49 - 6/50 0/50 - 3/50 Males 2/50 6/50 1/49 4/51 4/50 2/50 2/50 3/52 Females 0/50 0/50 0/50 0/50 3/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Trichoepithelioma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibroma Total 17/402(4.2%) 4/401(1%) Mean(sd) 4.3%(3.6) 1.0%(1.5) Range 0/52 - 6/50 0/50 - 2/50 Males 6/50 1/50 2/49 1/51 2/50 3/50 2/50 0/52 Females 2/50 1/50 0/50 0/50 0/50 1/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 22/402(5.5%) 8/401(2%) Sarcoma, Myxoma, Mean(sd) 5.5%(3.0) 2.0%(1.5) Myxosarcoma, or Fibrous Range 1/52 - 6/50 0/50 - 2/50 Histiocytoma Males 6/50 2/50 3/49 2/51 2/50 3/50 3/50 1/52 Females 2/50 2/50 0/50 1/50 0/50 1/50 1/50 1/51 --------------------------------------------------------------------------- Fibrosarcoma Total 3/402(0.7%) 1/401(0.2%) Mean(sd) 0.8%(1.0) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 1/49 1/51 0/50 0/50 0/50 0/52 Females 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 5/402(1.2%) 4/401(1%) Myxosarcoma, or Fibrous Mean(sd) 1.2%(1.0) 1.0%(1.1) Histiocytoma Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 1/49 1/51 0/50 0/50 1/50 1/52 Females 0/50 1/50 0/50 1/50 0/50 0/50 1/50 1/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Neurofibroma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Neurofibroma or Total 0/402(0%) 0/401(0%) Schwannoma benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 1/402(0.2%) 0/401(0%) Schwannoma (malignant or Mean(sd) 0.3%(0.7) 0.0%(0.0) NOS) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 1/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 1/402(0.2%) 0/401(0%) Neurofibroma, or Mean(sd) 0.3%(0.7) 0.0%(0.0) Schwannoma (benign, Range 0/50 - 1/50 0/50 - 0/50 malignant or NOS) Males 0/50 0/50 0/49 0/51 0/50 1/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 2/402(0.5%) 3/401(0.7%) Mean(sd) 0.5%(0.9) 0.8%(1.0) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 1/52 Females 0/50 0/50 0/50 1/50 0/50 0/50 1/50 1/51 --------------------------------------------------------------------------- Schwannoma Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 1/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Astrocytoma Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Chordoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Glioma Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibroma Total 2/398(0.5%) 0/400(0%) Mean(sd) 0.5%(1.4) 0.0%(0.0) Range 0/49 - 2/50 0/50 - 0/50 Males 0/49 0/50 0/48 0/49 0/50 0/50 2/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 1/398(0.3%) 0/400(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 1/49 0/50 0/48 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/398(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/398(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/398(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/398(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/398(0%) 0/400(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/49 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Basal Cell Adenoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Total 2/402(0.5%) 2/401(0.5%) Carcinoma or Papilloma Mean(sd) 0.5%(0.9) 0.5%(0.9) Squamous Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/402(0.5%) 2/401(0.5%) Mean(sd) 0.5%(0.9) 0.5%(0.9) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/49 0/51 1/50 0/50 0/50 0/52 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoid Tumor Benign Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/402(0%) 0/401(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 350/396(88.4%) Mean(sd) 88.3%(6.0) Range 38/50 - 47/50 Males 46/50 38/50 38/45 43/49 45/50 47/50 47/50 46/52 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Sarcoma Total 1/376(0.3%) 0/375(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/49 - 1/47 0/49 - 0/49 Males 0/49 0/45 1/47 0/46 0/47 0/42 0/49 0/51 Females 0/49 0/48 0/48 0/44 0/49 0/45 0/46 0/46 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/376(0%) 0/375(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/45 0/47 0/46 0/47 0/42 0/49 0/51 Females 0/49 0/48 0/48 0/44 0/49 0/45 0/46 0/46 --------------------------------------------------------------------------- Thymoma Benign Total 1/376(0.3%) 1/375(0.3%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/49 - 1/47 0/49 - 1/48 Males 0/49 0/45 0/47 0/46 1/47 0/42 0/49 0/51 Females 0/49 1/48 0/48 0/44 0/49 0/45 0/46 0/46 --------------------------------------------------------------------------- Thymoma Malignant Total 0/376(0%) 0/375(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/45 0/47 0/46 0/47 0/42 0/49 0/51 Females 0/49 0/48 0/48 0/44 0/49 0/45 0/46 0/46 --------------------------------------------------------------------------- Thymoma NOS Total 0/376(0%) 0/375(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/45 0/47 0/46 0/47 0/42 0/49 0/51 Females 0/49 0/48 0/48 0/44 0/49 0/45 0/46 0/46 --------------------------------------------------------------------------- Thymoma: Benign, Total 1/376(0.3%) 1/375(0.3%) Malignant, NOS Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/49 - 1/47 0/49 - 1/48 Males 0/49 0/45 0/47 0/46 1/47 0/42 0/49 0/51 Females 0/49 1/48 0/48 0/44 0/49 0/45 0/46 0/46 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/397(0%) 0/398(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/47 0/50 0/50 0/49 0/50 0/52 Females 0/50 0/50 0/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 30/397(7.6%) 27/398(6.8%) Mean(sd) 7.6%(5.2) 6.8%(5.3) Range 1/50 - 9/49 0/49 - 9/50 Males 5/50 9/49 1/47 1/50 3/50 4/49 4/50 3/52 Females 3/50 9/50 0/49 1/49 3/50 4/49 4/50 3/51 --------------------------------------------------------------------------- Carcinoma Total 7/397(1.8%) 2/398(0.5%) Mean(sd) 1.8%(2.3) 0.5%(0.9) Range 0/50 - 3/49 0/50 - 1/50 Males 1/50 3/49 1/47 0/50 2/50 0/49 0/50 0/52 Females 0/50 1/50 0/49 0/49 0/50 0/49 0/50 1/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 36/397(9.1%) 29/398(7.3%) Mean(sd) 9.1%(6.2) 7.3%(5.9) Range 1/50 - 11/49 0/49 - 10/50 Males 6/50 11/49 2/47 1/50 5/50 4/49 4/50 3/52 Females 3/50 10/50 0/49 1/49 3/50 4/49 4/50 4/51 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 10/397(2.5%) 6/398(1.5%) Mean(sd) 2.5%(2.6) 1.5%(2.3) Range 0/50 - 4/50 0/50 - 3/50 Males 0/50 2/49 0/47 1/50 4/50 1/49 1/50 1/52 Females 0/50 3/50 0/49 0/49 0/50 2/49 0/50 1/51 --------------------------------------------------------------------------- Carcinoma Total 5/397(1.3%) 2/398(0.5%) Mean(sd) 1.3%(1.0) 0.5%(0.9) Range 0/50 - 1/47 0/50 - 1/50 Males 0/50 1/49 1/47 1/50 1/50 0/49 0/50 1/52 Females 1/50 0/50 1/49 0/49 0/50 0/49 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 15/397(3.8%) 8/398(2%) Mean(sd) 3.8%(3.1) 2.0%(2.2) Range 0/50 - 5/50 0/49 - 3/50 Males 0/50 3/49 1/47 2/50 5/50 1/49 1/50 2/52 Females 1/50 3/50 1/49 0/49 0/50 2/49 0/50 1/51 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 1/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 1/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Osteosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Paraganglioma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Total 1/402(0.2%) 1/401(0.2%) Carcinoma or Papilloma Mean(sd) 0.3%(0.7) 0.3%(0.7) Squamous Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adamantinoma Benign Total 1/402(0.2%) 0/401(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 1/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Odontoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Carcinoma Total 0/393(0%) 0/396(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/45 0/49 0/50 0/49 0/49 0/51 Females 0/50 0/50 0/50 0/48 0/49 0/49 0/49 0/51 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 1/393(0.3%) 1/396(0.3%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/45 0/49 0/50 0/49 0/49 0/51 Females 0/50 1/50 0/50 0/48 0/49 0/49 0/49 0/51 --------------------------------------------------------------------------- Leiomyoma Total 0/393(0%) 0/396(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/45 0/49 0/50 0/49 0/49 0/51 Females 0/50 0/50 0/50 0/48 0/49 0/49 0/49 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/393(0%) 0/396(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/45 0/49 0/50 0/49 0/49 0/51 Females 0/50 0/50 0/50 0/48 0/49 0/49 0/49 0/51 --------------------------------------------------------------------------- Papilloma Total 1/393(0.3%) 1/396(0.3%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 0/45 0/49 0/50 0/49 0/49 0/51 Females 0/50 1/50 0/50 0/48 0/49 0/49 0/49 0/51 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Deciduoma Benign Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Deciduoma NOS Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibroma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Fibrosarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/401(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangioma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyoma Total 1/401(0.2%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/50 Females 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Polyp Stromal Total 63/401(15.7%) Mean(sd) 15.7%(3.5) Range 5/50 - 10/50 Females 9/50 5/50 7/50 9/50 6/50 10/50 9/50 8/51 --------------------------------------------------------------------------- Sarcoma Total 1/401(0.2%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/50 Females 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Stromal Total 8/401(2%) Mean(sd) 2.0%(2.1) Range 0/50 - 3/50 Females 1/50 2/50 0/50 0/50 0/50 1/50 3/50 1/51 --------------------------------------------------------------------------- Sarcoma Stromal or Total 69/401(17.2%) Polyp Stromal Mean(sd) 17.2%(4.5) Range 6/50 - 12/50 Females 10/50 6/50 7/50 9/50 6/50 11/50 12/50 8/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/401(0.2%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/51 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 --------------------------------------------------------------------------- Schwannoma NOS Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Fibrosarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Polyp Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Sarcoma Total 0/401(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/401(0.2%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/50 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS GAVAGE CORN OIL (Updated 12/99) Males(8 studies) Females(8 studies) =========================================================================== Adenoma Total 0/402(0%) 1/401(0.2%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma Total 2/402(0.5%) 0/401(0%) Mean(sd) 0.5%(0.9) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 1/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/402(0.5%) 1/401(0.2%) Mean(sd) 0.5%(0.9) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/49 0/51 1/50 0/50 0/50 1/52 Females 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/402(0%) 0/401(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/49 0/51 0/50 0/50 0/50 0/52 Females 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 ---------------------------------------------------------------------------