Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
Facility: TSI Mason Research
Chemical CAS #: 10326279
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 3| 5| 4| 8| 4| 2| 5| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 5| 4| 4| 4| 9| 5|
| 5| 5| 4| 8| 5| 7| 5| 6| 8| 5| 5| 5| 5| 5| 5| 8| 5| 5| 2| 8| 5| 5| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 3 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Congestion | |
Developmental Malformation | |
Fatty Change | 1 1 1 2 1 3 |
Granuloma | 1 1 3 1 2 2 1 2 |
Hemorrhage, Focal | |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Two | X X |
Bile Duct, Hyperplasia | 2 1 1 |
Hepatocyte, Hyperplasia, Focal | 3 3 3 3 |
Perivascular, Inflammation, Chronic | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Acinus, Atrophy, Focal | |
Acinus, Atrophy | 2 2 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Fibrosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Erosion | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 3| 5| 4| 8| 4| 2| 5| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 5| 4| 4| 4| 9| 5|
| 5| 5| 4| 8| 5| 7| 5| 6| 8| 5| 5| 5| 5| 5| 5| 8| 5| 5| 2| 8| 5| 5| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 2 2 2 1 3 2 2 2 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cytoplasmic Alteration, Focal | |
Infarct | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 2 1 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Cyst, Two | X |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + I + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Dilatation | 2 3 4 |
Thrombosis | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 3| 5| 4| 8| 4| 2| 5| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 5| 4| 4| 4| 9| 5|
| 5| 5| 4| 8| 5| 7| 5| 6| 8| 5| 5| 5| 5| 5| 5| 8| 5| 5| 2| 8| 5| 5| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 4 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Pancreatic, Lymphatic, Angiectasis | 4 |
Renal, Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Histiocytic, Lymphoid | 4 |
Infarct | |
Necrosis, Focal | |
Pigmentation, Hemosiderin | 2 1 |
__________________________________________________________________________|
Thymus | M + I + + + + + + + + + + + + + + + + + + M + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + M + M + + + +|
Galactocele | X |
Lactation | 4 3 |
__________________________________________________________________________|
Skin | + + + + + + M + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 4 4 2 |
Hemorrhage, Focal | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 1|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 4| 7| 7| 7| 5| 4|
DAY ON TEST | 4| 4| 3| 5| 4| 8| 4| 2| 5| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 5| 4| 4| 4| 9| 5|
| 5| 5| 4| 8| 5| 7| 5| 6| 8| 5| 5| 5| 5| 5| 5| 8| 5| 5| 2| 8| 5| 5| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Acute | 4 |
Inflammation, Chronic, Focal | 2|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 3 2 2 |
Metaplasia, Squamous | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Cataract | |
Degeneration | |
Synechia | 2 |
Cornea, Inflammation, Acute | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis, Focal | 4 |
Hypertrophy | 3 |
Nephropathy | 1 4 2 1 2 1 2 1 3 2 2 2 1 1 3 4 2 2 3 2 1 |
Pigmentation, Bile | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 4| 4| 5| 7| 6| 6| 4| 7| 7| 7| 5| 4| 7| 7| 6| 4| 3|
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 0| 5| 5| 8| 4| 9| 4| 5| 3| 4| 4| 7| 5| 4| 4| 2| 5| 8|
| 5| 5| 5| 5| 9| 5| 5| 6| 6| 6| 9| 5| 2| 5| 8| 9| 5| 5| 5| 6| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Congestion | |
Developmental Malformation | X X |
Fatty Change | 2 3 2 1 4 |
Granuloma | 2 2 2 2 2 2 |
Hemorrhage, Focal | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X |
Hepatodiaphragmatic Nodule, Two | |
Bile Duct, Hyperplasia | 2 2 |
Hepatocyte, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | 2 2 |
Serosa, Fibrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Acinus, Atrophy, Focal | 2 1 |
Acinus, Atrophy | 2 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Fibrosis | |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 4| 4| 5| 7| 6| 6| 4| 7| 7| 7| 5| 4| 7| 7| 6| 4| 3|
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 0| 5| 5| 8| 4| 9| 4| 5| 3| 4| 4| 7| 5| 4| 4| 2| 5| 8|
| 5| 5| 5| 5| 9| 5| 5| 6| 6| 6| 9| 5| 2| 5| 8| 9| 5| 5| 5| 6| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cytoplasmic Alteration, Focal | |
Infarct | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + M + M + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X|
Pars Distalis, Hyperplasia, Focal | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Cyst, Two | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Dilatation | |
Thrombosis | X |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 4| 4| 5| 7| 6| 6| 4| 7| 7| 7| 5| 4| 7| 7| 6| 4| 3|
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 0| 5| 5| 8| 4| 9| 4| 5| 3| 4| 4| 7| 5| 4| 4| 2| 5| 8|
| 5| 5| 5| 5| 9| 5| 5| 6| 6| 6| 9| 5| 2| 5| 8| 9| 5| 5| 5| 6| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + I + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 4 3 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Pancreatic, Lymphatic, Angiectasis | |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Congestion | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 3 1 3|
Hyperplasia, Histiocytic, Lymphoid | |
Infarct | 3 |
Necrosis, Focal | 3 |
Pigmentation, Hemosiderin | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M + + + + + + M + + + + + + + + + M +|
Galactocele | X X |
Lactation | 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 3 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage, Focal | 4 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 4| 4| 5| 7| 6| 6| 4| 7| 7| 7| 5| 4| 7| 7| 6| 4| 3|
DAY ON TEST | 4| 4| 4| 4| 5| 4| 4| 0| 5| 5| 8| 4| 9| 4| 5| 3| 4| 4| 7| 5| 4| 4| 2| 5| 8|
| 5| 5| 5| 5| 9| 5| 5| 6| 6| 6| 9| 5| 2| 5| 8| 9| 5| 5| 5| 6| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + A + +|
Cataract | 4 |
Degeneration | |
Synechia | |
Cornea, Inflammation, Acute | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis, Focal | 3 |
Hypertrophy | |
Nephropathy | 2 2 1 1 2 1 1 2 3 1 1 1 4 2 3 1 1 3 3 1 |
Pigmentation, Bile | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 6| 4| 4| | |
DAY ON TEST | 4| 4| 4| 4| 7| 8| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 7| 3| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + A + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A + + + | 57 |
Parasite Metazoan | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + A + + + | 57 |
Parasite Metazoan | | 5 3.4|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + A + + + | 57 |
Parasite Metazoan | 4 4 | 8 3.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + A + A + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + A + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + + + | 56 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 4.0|
Basophilic Focus | X X X X X X | 39 |
Clear Cell Focus | | 6 |
Congestion | 2 | 1 2.0|
Developmental Malformation | | 2 |
Fatty Change | 1 2 | 13 1.8|
Granuloma | 1 3 2 | 17 1.8|
Hemorrhage, Focal | | 1 2.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 7 |
Hepatodiaphragmatic Nodule, Two | | 2 |
Bile Duct, Hyperplasia | 1 | 6 1.5|
Hepatocyte, Hyperplasia, Focal | 2 | 5 2.8|
Perivascular, Inflammation, Chronic | 1 | 3 1.7|
Serosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 4 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Autolysis | 3 | 1 3.0|
Acinus, Atrophy, Focal | | 2 1.5|
Acinus, Atrophy | 2 | 10 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 6| 4| 4| | |
DAY ON TEST | 4| 4| 4| 4| 7| 8| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 7| 3| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | 2 | 1 2.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | | 1 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 1 3 1 2 | 23 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | 3 | 1 3.0|
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia, Focal | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + A + + + + + | 58 |
Pars Distalis, Cyst | X X | 8 |
Pars Distalis, Hyperplasia, Focal | | 7 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Cyst | X X | 12 |
Cyst, Two | | 1 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 6| 4| 4| | |
DAY ON TEST | 4| 4| 4| 4| 7| 8| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 7| 3| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Congestion | 2 | 1 2.0|
Cyst | X | 2 |
Dilatation | | 3 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Vagina | | 2 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 36 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hyperplasia | 3 | 13 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Congestion | 3 | 2 3.0|
Pancreatic, Lymphatic, Angiectasis | | 1 4.0|
Renal, Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | 1 | 5 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Congestion | | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | | 5 2.4|
Hyperplasia, Histiocytic, Lymphoid | | 1 4.0|
Infarct | | 1 3.0|
Necrosis, Focal | | 1 3.0|
Pigmentation, Hemosiderin | 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + | 54 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + | 52 |
Galactocele | X X X X | 7 |
Lactation | 2 | 5 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + M + | 57 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 6| 4| 4| | |
DAY ON TEST | 4| 4| 4| 4| 7| 8| 5| 5| 5| 5| | |
| 5| 5| 5| 5| 5| 7| 3| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 3 | 8 2.9|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 5 3.6|
Hemorrhage, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 4 4 | 4 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 4 | 3 3.3|
Inflammation, Acute | 3 | 3 3.0|
Inflammation, Chronic, Focal | 2 | 4 2.0|
Inflammation, Chronic | 2 2 2 3 2 2 3 2 | 38 2.1|
Metaplasia, Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 6 |
Cataract | | 1 4.0|
Degeneration | 4 | 1 4.0|
Synechia | | 1 2.0|
Cornea, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + A + + + | 58 |
Cyst | X | 1 |
Fibrosis, Focal | | 2 3.5|
Hypertrophy | | 1 3.0|
Nephropathy | 2 2 2 2 2 1 1 | 48 1.9|
Pigmentation, Bile | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + A A + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 4| 4| 4| 8| 5| 4| 4| 1| 5| 5| 4| 4| 4| 0| 5| 4| 4| 4| 4| 4| 4| 4| 0| 7| 5|
| 5| 5| 5| 9| 8| 4| 4| 3| 8| 6| 4| 4| 4| 6| 7| 5| 5| 5| 5| 5| 5| 5| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 3 4 4 3 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Developmental Malformation | X |
Fatty Change | 1 3 1 |
Granuloma | 2 1 2 3 4 1 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic, Focal | 1 |
Bile Duct, Hyperplasia | 2 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
Acinus, Atrophy | 1 2 2 |
__________________________________________________________________________|
Pharynx | |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 3 1 1 1 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 4| 4| 4| 8| 5| 4| 4| 1| 5| 5| 4| 4| 4| 0| 5| 4| 4| 4| 4| 4| 4| 4| 0| 7| 5|
| 5| 5| 5| 9| 8| 4| 4| 3| 8| 6| 4| 4| 4| 6| 7| 5| 5| 5| 5| 5| 5| 5| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 3 |
Cytoplasmic Alteration | 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + I + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 3 2 2 3 4 3 2|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Abscess, Two | 3 |
Cyst | X X |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Congestion | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2|
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 4| 4| 4| 8| 5| 4| 4| 1| 5| 5| 4| 4| 4| 0| 5| 4| 4| 4| 4| 4| 4| 4| 0| 7| 5|
| 5| 5| 5| 9| 8| 4| 4| 3| 8| 6| 4| 4| 4| 6| 7| 5| 5| 5| 5| 5| 5| 5| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Congestion | 2 1 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Granuloma | |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Histiocytic, Lymphoid | 4 |
Infarct | |
Pigmentation, Hemosiderin | 1 2 2 4 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M + + + + M + + + + + + + + + M|
Galactocele | X X X X |
Galactocele, Multiple | X |
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Melanin | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Metaplasia, Osseous | 4 |
Alveolar Epithelium, Metaplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4 4 3 |
Inflammation, Acute | 4 3 3 3 |
Inflammation, Chronic, Focal | 2 2|
Inflammation, Chronic | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 4| 4| 4| 8| 5| 4| 4| 1| 5| 5| 4| 4| 4| 0| 5| 4| 4| 4| 4| 4| 4| 4| 0| 7| 5|
| 5| 5| 5| 9| 8| 4| 4| 3| 8| 6| 4| 4| 4| 6| 7| 5| 5| 5| 5| 5| 5| 5| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 3 2 |
Hemorrhage | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | |
Mineralization | |
Nephropathy | 2 2 1 1 1 1 1 2 4 1 1 2 1 1 2 2 2 2 1|
Pigmentation, Bile | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 5| 4| 4| 4| 6| 5| 4| 4| 4| 4| 4| 0| 4| 4| 5| 2|
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 6| 8| 4| 4| 4| 4| 4| 7| 4| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 4 4 2 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Developmental Malformation | X X X X |
Fatty Change | 3 1 1 1 |
Granuloma | 4 2 2 3 2 3 2 3 3 2 2|
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Focal | |
Bile Duct, Hyperplasia | 2 2 1 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy | 4 1 4 |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia, Basal Cell | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 2 1 3 2 1 3 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 5| 4| 4| 4| 6| 5| 4| 4| 4| 4| 4| 0| 4| 4| 5| 2|
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 6| 8| 4| 4| 4| 4| 4| 7| 4| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 3 2 2 4 4 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 2 3 4 |
Abscess, Two | |
Cyst | X X |
Inflammation, Acute | 3 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + I + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 4 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 3|
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
Pancreatic, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Congestion | |
Infiltration Cellular, Plasma Cell | 3|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 5| 4| 4| 4| 6| 5| 4| 4| 4| 4| 4| 0| 4| 4| 5| 2|
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 6| 8| 4| 4| 4| 4| 4| 7| 4| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Granuloma | 4 |
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Histiocytic, Lymphoid | 4 4 |
Infarct | 3 |
Pigmentation, Hemosiderin | 1 2 3|
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Galactocele | X X X X X |
Galactocele, Multiple | |
Lactation | 4 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Melanin | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 2 3 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 4 X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Metaplasia, Osseous | |
Alveolar Epithelium, Metaplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 2 2 1 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4|
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 5| 4| 4| 4| 6| 5| 4| 4| 4| 4| 4| 0| 4| 4| 5| 2|
| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 6| 8| 4| 4| 4| 4| 4| 7| 4| 7| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 4 2 3 |
Hemorrhage | 2 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Mineralization | 1 |
Nephropathy | 1 2 1 1 2 2 1 2 1 2 1 1 3 1 1 2 2 1 1 1 1 1 |
Pigmentation, Bile | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| | |
DAY ON TEST | 4| 0| 0| 9| 5| 4| 4| 4| 5| 5| | |
| 4| 6| 6| 5| 6| 4| 4| 4| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 58 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 57 |
Parasite Metazoan | 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A M + + + + + M | 57 |
Parasite Metazoan | 2 | 13 3.2|
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X X | 43 |
Clear Cell Focus | X X | 4 |
Developmental Malformation | | 5 |
Fatty Change | 3 2 1 | 10 1.7|
Granuloma | 2 1 2 | 21 2.3|
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation, Chronic, Focal | | 1 1.0|
Bile Duct, Hyperplasia | 2 | 7 1.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + A A + + + + + + | 57 |
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Atrophy | | 6 2.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Hyperplasia, Basal Cell | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 2 3.0|
Hyperplasia, Basal Cell | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| | |
DAY ON TEST | 4| 0| 0| 9| 5| 4| 4| 4| 5| 5| | |
| 4| 6| 6| 5| 6| 4| 4| 4| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 1 2 | 28 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Cytoplasmic Alteration, Focal | | 1 3.0|
Cytoplasmic Alteration | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + | 58 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + + | 58 |
Pars Distalis, Cyst | X X | 8 |
Pars Distalis, Hyperplasia, Focal | 3 | 4 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 | 14 2.7|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Abscess | 3 | 6 2.8|
Abscess, Two | | 1 3.0|
Cyst | | 4 |
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Congestion | | 3 2.0|
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
Endometrium, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 37 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| | |
DAY ON TEST | 4| 0| 0| 9| 5| 4| 4| 4| 5| 5| | |
| 4| 6| 6| 5| 6| 4| 4| 4| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + | 59 |
Hyperplasia | | 11 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Congestion | | 4 2.5|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
Pancreatic, Congestion | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 58 |
Congestion | 2 1 2 | 6 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
Lymphatic, Angiectasis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + | 59 |
Autolysis | | 1 4.0|
Congestion | 4 2 | 6 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 | 2 2.0|
Granuloma | | 1 4.0|
Hematopoietic Cell Proliferation | 4 | 4 4.0|
Hyperplasia, Histiocytic, Lymphoid | | 3 4.0|
Infarct | | 1 3.0|
Pigmentation, Hemosiderin | 1 2 | 9 2.0|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + A M + + + + M + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M M + + + + + | 52 |
Galactocele | | 9 |
Galactocele, Multiple | X | 2 |
Lactation | | 2 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Pigmentation, Melanin | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 4 2 | 11 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 3 4 | 8 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| | |
DAY ON TEST | 4| 0| 0| 9| 5| 4| 4| 4| 5| 5| | |
| 4| 6| 6| 5| 6| 4| 4| 4| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Metaplasia, Osseous | | 1 4.0|
Alveolar Epithelium, Metaplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 5 3.8|
Inflammation, Acute | | 5 3.0|
Inflammation, Chronic, Focal | 2 1 | 7 1.7|
Inflammation, Chronic | 2 3 2 2 2 2 | 41 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Cataract | 3 | 6 2.8|
Hemorrhage | | 1 2.0|
Retina, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + | 58 |
Autolysis | 1 | 1 1.0|
Mineralization | | 1 1.0|
Nephropathy | 1 1 2 1 1 1 2 | 48 1.5|
Pigmentation, Bile | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A A + + + + + + | 57 |
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 5| 7| 4| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 2| 5| 4| 4| 4| 4| 5| 4| 4| 4| 6| 5| 5| 4| 4| 5| 3| 7| 4| 4| 4| 5|
| 3| 3| 3| 0| 6| 2| 2| 2| 1| 6| 2| 2| 2| 2| 8| 8| 1| 2| 6| 0| 3| 3| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 3 |
Muscularis, Hypertrophy | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 4 4 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 3 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
Artery, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Congestion | 1 |
Developmental Malformation | X |
Fatty Change | 1 1 1 |
Granuloma | 1 2 3 |
Hepatodiaphragmatic Nodule | X |
Bile Duct, Hyperplasia | 1 1 4 |
__________________________________________________________________________|
Mesentery | + |
Accessory Spleen | X |
Artery, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy | 3 1 3 2 |
Artery, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 1 1 2 1 2 2 1 2 2 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 5| 7| 4| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 2| 5| 4| 4| 4| 4| 5| 4| 4| 4| 6| 5| 5| 4| 4| 5| 3| 7| 4| 4| 4| 5|
| 3| 3| 3| 0| 6| 2| 2| 2| 1| 6| 2| 2| 2| 2| 8| 8| 1| 2| 6| 0| 3| 3| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M|
Congestion | 3 |
Cytoplasmic Alteration, Focal | 3 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
C-Cell, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Abscess, Two | |
Cyst | X X |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Endometrium, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 3 2 2 4 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 5| 7| 4| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 2| 5| 4| 4| 4| 4| 5| 4| 4| 4| 6| 5| 5| 4| 4| 5| 3| 7| 4| 4| 4| 5|
| 3| 3| 3| 0| 6| 2| 2| 2| 1| 6| 2| 2| 2| 2| 8| 8| 1| 2| 6| 0| 3| 3| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Infiltration Cellular, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Congestion | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage, Focal | 4 |
Pigmentation, Hemosiderin | 2 2 2 2 3 2|
__________________________________________________________________________|
Thymus | + + + + + I + + + I + + M + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Galactocele | X X X X X |
Galactocele, Multiple | X |
Lactation | 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration | 2 |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 4 |
Hemorrhage, Focal | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage, Focal | |
Alveolar Epithelium, Metaplasia | |
Alveolus, Metaplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 4| 5| 7| 4| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 2| 5| 4| 4| 4| 4| 5| 4| 4| 4| 6| 5| 5| 4| 4| 5| 3| 7| 4| 4| 4| 5|
| 3| 3| 3| 0| 6| 2| 2| 2| 1| 6| 2| 2| 2| 2| 8| 8| 1| 2| 6| 0| 3| 3| 3| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 1 1 2 2 1|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis, Focal | |
Nephropathy | 1 2 2 2 2 2 3 1 2 1 1 2 1 1 1 1 2 1 2 1 3 2 |
Papilla, Fibrosis, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 8| 1| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 5|
| 2| 2| 2| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 8| 8| 6| 4| 4| 4| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
Muscularis, Hypertrophy | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 3 3 2 2 3 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
Artery, Inflammation, Acute | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X|
Congestion | |
Developmental Malformation | X X X X |
Fatty Change | 3 2 2 2 |
Granuloma | 2 1 3 1 2 2 2 3 2 |
Hepatodiaphragmatic Nodule | X |
Bile Duct, Hyperplasia | 1 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | |
Artery, Inflammation, Chronic | 4 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy | 3 1 2 |
Artery, Inflammation, Acute | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 2 2 3 2|
Artery, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 8| 1| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 5|
| 2| 2| 2| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 8| 8| 6| 4| 4| 4| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cytoplasmic Alteration, Focal | 4 2 3 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Abscess, Two | 4 |
Cyst | X|
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Endometrium, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 1|
Mediastinal, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 8| 1| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 5|
| 2| 2| 2| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 8| 8| 6| 4| 4| 4| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Congestion | 3 1 |
Infiltration Cellular, Plasma Cell | 4 |
Pigmentation | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | |
Pigmentation, Hemosiderin | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M M|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M + + + M + + M + + + + + + + + + + + +|
Galactocele | X |
Galactocele, Multiple | |
Lactation | 2 |
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 2 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration | |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 4 |
Hemorrhage, Focal | 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 3 |
Alveolar Epithelium, Metaplasia | 4 4 |
Alveolus, Metaplasia | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 4| 4| 8| 1| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 4| 4| 5|
| 2| 2| 2| 3| 0| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 8| 8| 6| 4| 4| 4| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1250 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 4|
Inflammation, Acute | 3 2 3|
Inflammation, Chronic, Focal | 2 1 2 |
Inflammation, Chronic | 2 2 4 3 2 2 2 2 2 2 2 3 2 2 2 2 2 |
Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Fibrosis, Focal | 2 4 |
Nephropathy | 2 2 2 2 2 2 1 2 1 1 2 3 3 3 1 1 1 3 3 2 2 1|
Papilla, Fibrosis, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 3| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Parasite Metazoan | 3 | 4 2.5|
Muscularis, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 2 2 | 8 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | 3 | 11 2.8|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 2.0|
Artery, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Basophilic Focus | X X X X X X X X X | 41 |
Clear Cell Focus | X X X | 8 |
Congestion | | 1 1.0|
Developmental Malformation | | 5 |
Fatty Change | 2 | 8 1.8|
Granuloma | 2 3 3 2 2 | 17 2.1|
Hepatodiaphragmatic Nodule | X | 3 |
Bile Duct, Hyperplasia | 2 | 9 1.9|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Accessory Spleen | | 1 |
Artery, Inflammation, Chronic | | 1 4.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy, Focal | | 2 2.0|
Acinus, Atrophy | 4 4 | 9 2.6|
Artery, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Artery, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 3| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 1 1 1 | 27 1.7|
Artery, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + | 58 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + | 58 |
Congestion | | 1 3.0|
Cytoplasmic Alteration, Focal | | 4 3.0|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + | 58 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 3 | 3 2.7|
Pars Distalis, Cyst | | 4 |
Pars Distalis, Hyperplasia, Focal | | 4 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 5 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Abscess | | 2 3.5|
Abscess, Two | | 1 4.0|
Cyst | | 3 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 3| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Hyperplasia | 1 3 | 9 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Congestion | | 2 1.5|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Congestion | | 3 1.7|
Infiltration Cellular, Plasma Cell | | 1 4.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion, Focal | | 1 2.0|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage, Focal | | 1 4.0|
Pigmentation, Hemosiderin | | 10 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 54 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 55 |
Galactocele | X X | 8 |
Galactocele, Multiple | | 1 |
Lactation | 4 | 4 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Hyperkeratosis | 4 | 1 4.0|
Hyperplasia, Basal Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 3 4 4 | 10 3.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 3| 3| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1250 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Degeneration | | 1 2.0|
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 4 4.0|
Hemorrhage, Focal | | 1 2.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Hemorrhage, Focal | | 1 3.0|
Alveolar Epithelium, Metaplasia | | 2 4.0|
Alveolus, Metaplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 4 | 3 4.0|
Inflammation, Acute | 4 | 4 3.0|
Inflammation, Chronic, Focal | | 8 1.5|
Inflammation, Chronic | 2 2 2 2 3 2 2 2 | 42 2.1|
Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | 3 | 2 3.0|
Fibrosis, Focal | | 2 3.0|
Nephropathy | 3 1 2 1 3 1 1 2 3 | 53 1.8|
Papilla, Fibrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 6| 3| 3| 3| 5| 5| 3| 3| 9| 7| 5| 0| 3| 4| 4| 5| 4| 4| 4| 4| 9|
| 1| 1| 1| 1| 9| 7| 7| 7| 6| 6| 7| 0| 2| 9| 8| 7| 7| 1| 1| 6| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Infiltration Cellular, Lymphocyte | |
Parasite Metazoan | 1 |
Muscularis, Hypertrophy | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 3 4 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Cytoplasmic Alteration, Focal | 2 |
Developmental Malformation | X X |
Fatty Change | 3 4 3|
Granuloma | 3 1 3 1 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Acute, Focal | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 2 1 2 3 |
Hepatocyte, Hyperplasia, Focal | 2 |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Acinus, Atrophy, Focal | 1 |
Acinus, Atrophy | 2 1 1 1 1 3 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Bulla | |
Edema | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 6| 3| 3| 3| 5| 5| 3| 3| 9| 7| 5| 0| 3| 4| 4| 5| 4| 4| 4| 4| 9|
| 1| 1| 1| 1| 9| 7| 7| 7| 6| 6| 7| 0| 2| 9| 8| 7| 7| 1| 1| 6| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | |
Mineralization | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 1 1 1 3 2 1 1 1 2 |
Mineralization | 2 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Cyst, Two | X |
Inflammation, Acute | 2 2 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X |
Granuloma | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 6| 3| 3| 3| 5| 5| 3| 3| 9| 7| 5| 0| 3| 4| 4| 5| 4| 4| 4| 4| 9|
| 1| 1| 1| 1| 9| 7| 7| 7| 6| 6| 7| 0| 2| 9| 8| 7| 7| 1| 1| 6| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | |
Prolapse | |
Endometrium, Cyst | X X |
Endometrium, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Congestion | 2 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Depletion Lymphoid | 3 |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | |
Pigmentation, Hemosiderin | 2 2 4 2 2 4|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 3 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage, Focal | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 6| 3| 3| 3| 5| 5| 3| 3| 9| 7| 5| 0| 3| 4| 4| 5| 4| 4| 4| 4| 9|
| 1| 1| 1| 1| 9| 7| 7| 7| 6| 6| 7| 0| 2| 9| 8| 7| 7| 1| 1| 6| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Alveolar Epithelium, Metaplasia | |
Bronchus, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic, Focal | 1 2 |
Inflammation, Chronic | 2 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3|
Nephropathy | 2 2 2 4 1 1 2 2 1 2 2 2 2 2 2 3 1 1 1 1 2 3|
Papilla, Necrosis | 4 |
Renal Tubule, Pigmentation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 7| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 4| 1| 5| 4| 4| 1| 4| 5| 4| 4| 2| 9| 5| 4| 0| 5| 2| 5| 4| 4| 3| 4| 4|
| 1| 0| 7| 0| 6| 1| 1| 7| 1| 8| 2| 2| 1| 3| 8| 2| 7| 0| 7| 6| 2| 2| 8| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Infiltration Cellular, Lymphocyte | 3 |
Parasite Metazoan | 3 2 |
Muscularis, Hypertrophy | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 4 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Cytoplasmic Alteration, Focal | |
Developmental Malformation | |
Fatty Change | 4 3 2 2 1 2|
Granuloma | 3 2 4 3 2 3 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Acute, Focal | 3 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 2 1 |
Hepatocyte, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Acinus, Atrophy, Focal | |
Acinus, Atrophy | 2 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Bulla | 3 |
Edema | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 7| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 4| 1| 5| 4| 4| 1| 4| 5| 4| 4| 2| 9| 5| 4| 0| 5| 2| 5| 4| 4| 3| 4| 4|
| 1| 0| 7| 0| 6| 1| 1| 7| 1| 8| 2| 2| 1| 3| 8| 2| 7| 0| 7| 6| 2| 2| 8| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 2 3 1 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 4 4 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + I + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X X |
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + M I + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia, Focal | 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 2 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | |
Cyst, Two | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X X |
Granuloma | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 7| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 4| 1| 5| 4| 4| 1| 4| 5| 4| 4| 2| 9| 5| 4| 0| 5| 2| 5| 4| 4| 3| 4| 4|
| 1| 0| 7| 0| 6| 1| 1| 7| 1| 8| 2| 2| 1| 3| 8| 2| 7| 0| 7| 6| 2| 2| 8| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | |
Prolapse | X |
Endometrium, Cyst | X |
Endometrium, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 4 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 4 2 3 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 1 |
Lymphatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | |
Lymphatic, Angiectasis | 3 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage, Focal | 3|
Pigmentation, Hemosiderin | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 4 2 3 3 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 4 3 2 |
Hemorrhage, Focal | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 6| 7| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 4| 1| 5| 4| 4| 1| 4| 5| 4| 4| 2| 9| 5| 4| 0| 5| 2| 5| 4| 4| 3| 4| 4|
| 1| 0| 7| 0| 6| 1| 1| 7| 1| 8| 2| 2| 1| 3| 8| 2| 7| 0| 7| 6| 2| 2| 8| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Alveolar Epithelium, Metaplasia | 3 |
Bronchus, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Inflammation, Acute | 3 |
Inflammation, Chronic, Focal | 1 2 |
Inflammation, Chronic | 2 2 3 2 2 3 2 2 2 2 2 2 2 4 2 2 2 2|
Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
__________________________________________________________________________|
Zymbal's Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Nephropathy | 2 4 2 1 1 2 2 2 3 1 1 2 1 2 1 2 2 2 1 1 1|
Papilla, Necrosis | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 6| 6| 4| 4| 4| 4| 4| 4| 5| 5| | |
| 3| 9| 1| 1| 1| 1| 1| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Parasite Metazoan | | 3 2.0|
Muscularis, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | 4 | 8 3.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | X X X X X X X | 40 |
Clear Cell Focus | X X X X | 11 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Developmental Malformation | | 2 |
Fatty Change | 2 | 10 2.6|
Granuloma | 2 1 | 14 2.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 6 |
Inflammation, Acute, Focal | | 1 3.0|
Necrosis, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 | 9 1.6|
Hepatocyte, Hyperplasia, Focal | | 1 2.0|
Perivascular, Inflammation, Chronic | 1 | 5 1.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Necrosis | 4 | 1 4.0|
Acinus, Atrophy, Focal | 4 | 2 2.5|
Acinus, Atrophy | 2 2 4 2 | 14 1.9|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 6| 6| 4| 4| 4| 4| 4| 4| 5| 5| | |
| 3| 9| 1| 1| 1| 1| 1| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis | | 2 3.0|
Bulla | | 1 3.0|
Edema | 4 | 1 4.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic, Focal | | 2 1.5|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 3 1 3 1 2 2 | 27 1.9|
Mineralization | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Cytoplasmic Alteration, Focal | | 4 3.5|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + M + + + + + + + | 59 |
Ectopic Tissue | | 2 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 55 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | X | 9 |
Pars Distalis, Hyperplasia, Focal | | 3 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 2 2 | 8 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Cyst | X | 5 |
Cyst, Two | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 6| 6| 4| 4| 4| 4| 4| 4| 5| 5| | |
| 3| 9| 1| 1| 1| 1| 1| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic, Focal | | 2 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Cyst | X | 5 |
Granuloma | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Cyst | | 1 |
Dilatation | 4 | 1 4.0|
Prolapse | | 1 |
Endometrium, Cyst | | 3 |
Endometrium, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + | 32 |
__________________________________________________________________________|____________|
Bone Marrow | + + + I + + + + + + | 59 |
Hyperplasia | 4 | 10 3.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Congestion | 4 | 6 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
Mediastinal, Pigmentation | 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Congestion | 2 | 5 1.8|
Lymphatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Congestion | 3 | 3 2.7|
Depletion Lymphoid | | 1 3.0|
Lymphatic, Angiectasis | | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage, Focal | | 1 3.0|
Pigmentation, Hemosiderin | 3 2 | 12 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 6| 6| 4| 4| 4| 4| 4| 4| 5| 5| | |
| 3| 9| 1| 1| 1| 1| 1| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Galactocele | | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 4 4 | 11 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 4 3 | 8 3.3|
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 | 3 1.3|
Alveolar Epithelium, Metaplasia | 3 | 2 3.0|
Bronchus, Metaplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 2 3.5|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic, Focal | 2 2 | 6 1.7|
Inflammation, Chronic | 2 2 2 1 2 3 2 2 | 45 2.2|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 1 | 3 2.0|
Nephropathy | 3 3 2 3 3 2 2 2 1 | 52 1.9|
Papilla, Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 6| 6| 4| 4| 4| 4| 4| 4| 5| 5| | |
| 3| 9| 1| 1| 1| 1| 1| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 6| 6| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 0| 7| 4| 4| 3| 3| 0| 8| 8| 3| 3| 5| 5| 5| 8| 9| 3| 0| 5| 3| 3| 2| 8| 5|
| 3| 8| 3| 3| 3| 3| 4| 8| 7| 4| 6| 3| 3| 2| 2| 1| 1| 6| 1| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A + + + + + + A + + + + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + A + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + A + + + + + + A + + + + + + + + +|
Parasite Metazoan | 4 4 |
__________________________________________________________________________|
Intestine Small | + + A + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Congestion | |
Cytoplasmic Alteration, Focal | 2 |
Developmental Malformation | |
Fatty Change | 2 2 1 1 2 1 3 2 2 1|
Granuloma | 1 |
Hepatodiaphragmatic Nodule | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 3 2 3 3 4 2 4 2 1 1 2 3 2 4 3 2 2 1|
Hepatocyte, Hyperplasia, Focal | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + A + + + + + M + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 1 |
Acinus, Atrophy | 1 1 2 1 1 4 |
__________________________________________________________________________|
Pharynx | + + |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2|
Mineralization | |
__________________________________________________________________________|
Tongue | + |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 6| 6| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 0| 7| 4| 4| 3| 3| 0| 8| 8| 3| 3| 5| 5| 5| 8| 9| 3| 0| 5| 3| 3| 2| 8| 5|
| 3| 8| 3| 3| 3| 3| 4| 8| 7| 4| 6| 3| 3| 2| 2| 1| 1| 6| 1| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 1 2 2 2 2 2 2 2 2 1 2 3 |
Dilatation | 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cytoplasmic Alteration, Focal | |
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 |
Hyperplasia, Focal, Two | |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X|
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | 2 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +|
Abscess | |
Hyperplasia, Focal | |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2 3 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 6| 6| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 0| 7| 4| 4| 3| 3| 0| 8| 8| 3| 3| 5| 5| 5| 8| 9| 3| 0| 5| 3| 3| 2| 8| 5|
| 3| 8| 3| 3| 3| 3| 4| 8| 7| 4| 6| 3| 3| 2| 2| 1| 1| 6| 1| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 4 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Infiltration Cellular, Plasma Cell | |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 3 2 3 3 4 |
Infarct | 4 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + I + + + + + + M + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + M + + + + + M + + + + + + + + +|
Galactocele | |
Lactation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Fibrosis | 3 |
Hyperkeratosis | 4 |
Thrombosis | X |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4 4 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 6| 6| 7| 7| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 0| 7| 4| 4| 3| 3| 0| 8| 8| 3| 3| 5| 5| 5| 8| 9| 3| 0| 5| 3| 3| 2| 8| 5|
| 3| 8| 3| 3| 3| 3| 4| 8| 7| 4| 6| 3| 3| 2| 2| 1| 1| 6| 1| 3| 3| 3| 2| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
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NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 |
Alveolar Epithelium, Metaplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fungus | 4 4 3 4 4 3 4 |
Inflammation, Acute | 4 3 3 4 4 3 3 2 |
Inflammation, Chronic, Focal | 1 2 2 1|
Inflammation, Chronic | 2 2 2 2 3 2 2 2 2 3 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
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SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | A + |
Cataract | 2 |
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URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cyst | |
Mineralization | |
Nephropathy | 2 2 2 2 1 3 4 2 2 2 4 4 2 1 2 2 3 3 2 3 3 2 1|
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + A + + + + + + A + + + + + + A + +|
Calculus Micro Observation Only | X |
Ectasia | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05127-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BARIUM CHLORIDE DIHYDRATE Date: 04/24/97
Route: DOSED WATER Time: 07:35:59
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| 6| 7| 7| 7| 7| 6| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 7| 4|
DAY ON TEST | 1| 3| 3| 3| 2| 0| 3| 3| 7| 5| 3| 2| 0| 7| 5| 3| 3| 8| 5| 0| 6| 0| 3| 0| 5|
| 2| 4| 4| 3| 3| 5| 6| 6| 1| 3| 6| 2| 8| 3| 5| 4| 3| 2| 2| 5| 5| 3| 5| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + A +|
Parasite Metazoan | 2 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + A +|
Parasite Metazoan | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + A +|
Parasite Metazoan | 3 3 4 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X |
Congestion | 1|
Cytoplasmic Alteration, Focal | |
Developmental Malformation | X X X |
Fatty Change | 1 1 3 1 |
Granuloma | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Necrosis, Focal | 3 |
Bile Duct, Hyperplasia | 2 1 2 3 1 2 2 4 2 2 3 2 1 4 3 3 2 2 1 3 2 |
Hepatocyte, Hyperplasia, Focal | 3 |
Serosa, Fibrosis | 3 |
__________________________________________________________________________|
Mesentery | + + +|
Accessory Spleen | X |
Fat, Necrosis | 4 3|
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + A + + + M +|
Acinus, Atrophy, Focal | 3|
Acinus, Atrophy | 3 1 3 2 2 4 3 2 3 |
__________________________________________________________________________|
Pharynx | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
___________________________________