National Toxicology Program

CASRN: 17026-81-2

Formula: C10-H14-N2-O2

Synonyms/Common Names:

• N-(3-AMINO-4-ETHOXYPHENOL)-ACETAMIDE (9CI)

Known Uses:

Azo dye intermediate

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01887)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01887)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.05,.74 %/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01887)  Report Complete 
  • TR-112 (NIH Number: 78-1367; NTIS Number: PB285194)  (Peer Review Approval 04/26/1978A )
    Bioassay of 3-Amino-4-ethoxyacetanilide for Possible Carcinogenicity (CASRN 17026-81-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Negative 
  • Dose: R: 0,.4,1.5, M: 0,.4,.8 %/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (580234)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberation Negative 
• Drosophila  (866867)  Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella (NCI)  (CV-325)  Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella
  • Salmonella-NCI  Positive 
• Salmonella  (851003)  Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive