Nominations in Review 2009 (Spring)
Substances studied by the NTP are selected primarily on the basis of known or anticipated human exposure, production levels, suspicion of toxicity based on chemical structure or existing health effects data, availability of toxicological data, and extent of public concern. Selection of a substance for study does not imply that the substance is hazardous or a potential carcinogen in laboratory animals; likewise, when substances are not selected for toxicological evaluation by the Program, this should not be taken to mean that the substance is not potentially hazardous or potentially carcinogenic in laboratory animals. Nominated substances in the table below are identified by a common or generic name and CAS Registry No. where appropriate.
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)
* Note: The terms "initial toxicological characterization" and "comprehensive toxicological characterization" in this table refer to the approximate scope of a research program to address toxicological data needs. The types of toxicological studies that would be considered by NTP staff during the conceptualization and design of a research program for each are:
- Initial toxicological characterization: biomolecular screening, in vitro mechanistic, in vitro and in vivo genotoxicity, absorption, disposition, metabolism, and elimination, and short-term repeat dose (2-4 weeks) in vivo studies
- Comprehensive toxicological characterization: all of the aforementioned plus subchronic toxicity (13-26 weeks), chronic toxicity (1-2 years), carcinogenicity in conventional or genetically modified rodent models, organ systems toxicity (immunotoxicity, reproductive and developmental toxicity, neurotoxicity), in vivo mechanistic, toxicokinetics, and other special studies as appropriate (e.g. chemistry, toxicogenomics, phototoxicity).
Learn more about NTP Study Types.
For information, questions or comments, contact:
Dr. Scott A. Masten
Director, Office of Nomination and Selection
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)
|
Substance
[CAS No.] |
Nomination Source |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
|---|---|---|---|
Alkylanilines  (512 kb)
3-Ethylaniline [587-02-0] 3,5-Dimethylaniline [108-69-0] |
National Institute of Environmental Health Sciences | Potential for human exposure from a variety of industrial and ambient sources; suspicion of toxicity based on chemical structure; insufficient data to characterize toxicity of this aniline subclass | Initial toxicological characterization |
|
Substance
[CAS No.] |
Nomination Source |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
|---|---|---|---|
|
1-Chloro-4-(trifluoromethyl)benzene
(508 kb) [98-56-6] |
Kowa American Corp. | High production volume; increasing industrial and potential consumer use; lack of workplace exposure standards; lack of chronic toxicity data | Comprehensive toxicological characterization including developmental and reproductive toxicity and chronic toxicity/carcinogenicity studies |
|
Substance
[CAS No.] |
Nomination Source |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
|---|---|---|---|
|
Deoxynivalenol
(932 kb) [51481-10-8] |
National Institute of Environmental Health Sciences | Widespread environmental occurrence and potential for human exposure through consumption of contaminated foods; demonstrated toxicological activity; lack of definitive carcinogenicity and reproductive toxicity studies | Comprehensive toxicological characterization including reproductive toxicity and chronic toxicity/carcinogenicity studies |
|
Substance
[CAS No.] |
Nomination Source |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
|---|---|---|---|
|
Dong quai(2.8 mb)
(Angelica sinensis root [308068-61-3] and extract [299184-76-2])
|
Private Individual | Widespread use as a dietary supplement; suspicion of toxicity based on estrogenic activity and chemical structure; lack of adequate toxicity data | Comprehensive toxicological characterization including phototoxicity studies |
|
Substance
[CAS No.] |
Nomination Source |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
|---|---|---|---|
|
Indium tin oxide (556 kb)
[50926-11-9] |
National Institute of Environmental Health Sciences | Increasing production and use; documented pulmonary effects in exposed workers; suspicion of toxicity based on chemical structure; lack of adequate toxicity data | Comprehensive toxicological characterization |
|
Substance
[CAS No.] |
Nomination Source |
Nomination Rationale
(Principles) |
Preliminary Study Recommendations |
|---|---|---|---|
|
Tris(4-chlorophenyl)methane (388 kb) [27575-78-6] and Tris(4-chlorophenyl)methanol (388 kb)
[3010-80-8] |
National Institute of Environmental Health Sciences | Widespread occurrence and persistence in the environment; suspicion of toxicity based on anti-androgenic activity; lack of adequate toxicity data | Initial toxicological characterization |
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